abstract：:Aim of the present study was to evaluate the potential beneficial and/or adverse effects of Capsicum annuum L. (cv. Fiesta) extracts at two stage of ripening (immature and mature), and at two dosages (low and high) by evaluation of biochemical profile and oxidative status in CD-1 mice. The extracts were daily administ...

journal_title：Natural product research

authors： Morittu VM,Pero ME,Musco N,Mastellone V,Tudisco R,Provenzano E,Britti D,Menichini F,Infascelli F,Lombardi P

更新日期：2020-06-01 00:00:00

abstract：:Armoracia rusticana (AR) was tested for antimicrobial and antioxidants power. The compound demonstrated to inhibit fish pathogens such as Vibrio anguillarum, V. harvey, V. alginolyticus, Aeromonas hydrophila, A. salmonicida, Photobacterium damselae subspecie piscicida, Tenacibaculum marinum and Pseudomonas anguillisep...

journal_title：Natural product research

authors： Manuguerra S,Caccamo L,Mancuso M,Arena R,Rappazzo AC,Genovese L,Santulli A,Messina CM,Maricchiolo G

更新日期：2020-06-01 00:00:00

abstract：:One new limonoid, named siamensinolide (1), together with two known limonoids (2 and 3) and eight carbazole alkaloids (4-11) were isolated from the twigs of Chalcas siamensis Tanaka. Their structures were elucidated by spectroscopic methods, mainly 1D and 2D NMR spectroscopy. O-methylclausenolide (2) displayed strong ...

journal_title：Natural product research

authors： Boonyaketgoson S,Rukachaisirikul V,Phongpaichit S,Trisuwan K

更新日期：2020-05-25 00:00:00

abstract：:Two new, aramatosides A and B (1 and 2), together with seven known oleanane-type triterpene saponins (3-9) were isolated from the leaves of Aralia armata. Their structures were determined by combination of HR-ESI-MS, 1 D and 2 D NMR spectral data as well as comparison with the previous literature. Compounds 6-9 exhibi...

journal_title：Natural product research

authors： Yen PH,Chuong NTH,Lien GTK,Cuc NT,Nhiem NX,Thanh NTV,Tai BH,Seo Y,Namkung W,Park S,Kim SH,Minh CV,Kiem PV

更新日期：2020-05-22 00:00:00

abstract：:A novel oxime polyketide, maydisone (1), along with two known compounds, 7-hydroxy-2,5-dimethylchromone (2) and 2,5-dimethylbenzoic acid (3) were isolated from the cultures of Bipolaris maydis. Their structures were identified by the application of NMR and MS data analyses and comparison with previous reports. Compoun...

journal_title：Natural product research

authors： Tran TM,Nguyen VK,Duong TH,Tran TN,Nguyen NH,Devi AP,Chavasiri W,Dinh MH,Tran NM,Sichaem J

更新日期：2020-05-13 00:00:00

abstract：:Two new ergosterol derivatives namely, chlamydosterols A [(22E,24R)-ergosta-7,22-diene-3β,5α,6β-triol 6-decanoate] (1) and B [5α,6β,25-trihydroxy-(22E,24R)-ergosta-7,22-dien-3-one] (5) and three known ergosterols: ergosta-7,22-dien-3β-ol (2), ergosta-5,7,22-triene-3β-ol (3), and ergosta-7,22-diene-3β,5α,6β-triol (4) w...

journal_title：Natural product research

authors： Al-Rabia MW,Mohamed GA,Ibrahim SRM,Asfour HZ

更新日期：2020-05-06 00:00:00

abstract：:Several factors affect the vegetative growth of fungi, such as temperature, pH, and culture medium. In addition to mycelial growth, these factors affect metabolite production. There are limited studies that have identified the metabolites produced by the fungus Bjerkandera adusta, which have potential biotechnological...

journal_title：Natural product research

authors： Rech KS,de Oliveira CF,Moura PF,de Oliveira CDSP,Hirota BCK,de Oliveira M,Rüdiger AL,de Sá EL,Miguel OG,Auer CG,Miguel MD

更新日期：2020-05-06 00:00:00

abstract：:Toxicity of the pesticide carbofuran (CF) can be alleviated by curcumin, if not for its poor bioavailability. Hence, we investigated the effect of a bioavailable curcumin-galactomannan complex (CGM) on CF-induced neurotoxicity in rats in comparison to that of unformulated standard curcumin (CS). The CF (5 mg/kg b.wt/d...

journal_title：Natural product research

authors： E R S,P P B,Nair SS,Maliakel B,Kuttan R,I M K

更新日期：2020-05-01 00:00:00

abstract：:In the present study, evaluation of the antiproliferative activity of Pachypodium lamerei Drake leaves (family Apocyaceae) against human breast cancer cell lines MDA-MB-231 was done for the total methanolic extract, crude alkaloidal mixture and ursolic acid using the MTT colorimetric assay. The methanolic extract show...

journal_title：Natural product research

authors： Mina SA,Mohamed SA,Melek FR,Abd El-Khalik SM

更新日期：2020-05-01 00:00:00

abstract：:As part of our continuing efforts to explore bioactive compounds from natural resources, a new iridoid glycoside, adoxosidic acid-6'-oleuroperic ester (1), together with one known phenylethanoid glycoside (2) and two known flavonoid glycosides (3-4) were isolated from the fruit of Forsythia suspensa. The structure of ...

journal_title：Natural product research

authors： Wei Q,Zhang R,Wang Q,Yan XJ,Yu QW,Yan FX,Li C,Pei YH

更新日期：2020-05-01 00:00:00

abstract：:Essential oils from aerial parts of Senecio nutans, Senecio viridis, Tagetes terniflora and Aloysia gratissima were analysed by GC-MS and their antifungal activities were assayed on toxigenic Fusarium and Aspergillus species. Sabinene (27.6 ± 0.1%), α-phellandrene (15.7 ± 0.3%), o-cymene (9.6 ± 0.2%) and β-pinene (6.1...

journal_title：Natural product research

authors： Galvez CE,Jimenez CM,Gomez ALA,Lizarraga EF,Sampietro DA

更新日期：2020-05-01 00:00:00

abstract：:Three new neolignan derivatives (1-3), together with three known isolariciresinol derivatives (4-6) were isolated from Selaginella picta. Their structures were elucidated by spectroscopic methods (1D/2D NMR, HRESIMS and CD). All isolated compounds were assayed on the neuroprotective activity against the injury of HT-2...

journal_title：Natural product research

authors： Cheng F,Zou ZX,Xu PS,Zhang SH,Zhang Y,Yao CP,Xu KP,Tan GS

更新日期：2020-05-01 00:00:00

abstract：:In this study, Box-Behnken Design was used to optimize the ultrasonic extraction of polysaccharides from quince peels (QPPs) by ascorbic acid and the effect of extraction temperature, extraction time and pH was evaluated. Under optimized conditions of temperature 90 °C, 60 min sonication time and pH = 3.26, the extrac...

journal_title：Natural product research

authors： Dammak MI,Mzoughi Z,Chakroun I,Mansour HB,Le Cerf D,Majdoub H

更新日期：2020-05-01 00:00:00

abstract：:Two new neoclerodane diterpenoids, barbatin F (1), barbatin G (2) together with four known compounds, scutebata A (3), scutebata B (4), scutebata C (5) and scutebata P (6) were isolated from the whole plant of Scutellaria barbata D.Don. Their structures were elucidated on the basis of spectroscopic studies. In vitro c...

journal_title：Natural product research

authors： Wang M,Chen Y,Hu P,Ji J,Li X,Chen J

更新日期：2020-05-01 00:00:00

abstract：:Chemical investigation of the stems of Epigunum griffithianum led to the isolation and identification of a new triterpenoid saponin (1) and two known compounds (epigynosides A (2) and B (3)). These structures were elucidated by means of spectroscopic analysis (1D and 2D NMR, MS, UV, IR) as well as comparison with the ...

journal_title：Natural product research

authors： Wang Q,Li WY,Wang YD

更新日期：2020-05-01 00:00:00

abstract：:Inhibitory activity of the biocontrol bacterial strain Lysobacter capsici AZ78 is related to the production of cyclo(l-Pro-l-Tyr), a 2,5-diketopiperazine with in vitro and in vivo toxic activity against Phytophthora infestans and Plasmopara viticola. Further investigation of culture filtrate organic extracts showed it...

journal_title：Natural product research

authors： Cimmino A,Bejarano A,Masi M,Puopolo G,Evidente A

更新日期：2020-04-30 00:00:00

abstract：:Accumulating evidences have shown the beneficial effects of natural products for Alzheimer's disease (AD) treatment. The present study was designed to investigate the neuroprotective effects of secondary metabolites of Galactomyces geotrichum (SMGG) on D-galactose induced AD mice. SMGG was extracted and its toxicologi...

journal_title：Natural product research

authors： Wang F,Wang F,Chen T

更新日期：2020-04-15 00:00:00

abstract：:Sasa coreana Nakai (SCN) is a medicinal plant commonly used against inflammation. However, the underlined mechanisms against skin inflammation is poorly understood. The present study investigated the effects of SCN leave extract on ear inflammation. To this aim, six-week-old male ICR mice was subjected to 12-O-tetrade...

journal_title：Natural product research

authors： Khan I,Dey DK,Lee JH,Kang SC

更新日期：2020-04-14 00:00:00

abstract：:A new pterocarpan, named velucarpin D (1), along with nine known pterocarpans (2-10) were isolated from the stems of Dalbergia velutina. Their structures were determined by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines (KB, HeLa S-3, MCF-7, He...

journal_title：Natural product research

authors： Kaennakam S,Sukandar ER,Hongnak S,Rassamee K,Siripong P,Tip-Pyang S

更新日期：2020-04-05 00:00:00

abstract：:Two diketopiperazines were isolated from a culture of the marine-derived actinomycete Streptomyces sp. ZZ446. Their structures were elucidated as maculosin (1) and maculosin-O-α-L-rhamnopyranoside (2) based on their NMR and HRESIMS data, specific rotation, and chemical degradation. Maculosin-O-α-L-rhamnopyranoside (2)...

journal_title：Natural product research

authors： Chen S,Zhang D,Chen M,Zhang Z,Lian XY

更新日期：2020-04-01 00:00:00

abstract：:One new neolignan glycoside, dolomiside A (1), together with 11 known phenylpropanoid glycosides were isolated from Dolomiaea souliei (Franch.) Shih. The structures of these isolates were determined by UV, CD, HR-ESI-TOFMS, 1D and 2D NMR analysis. ...

journal_title：Natural product research

authors： Yi M,Meng FC,Qu SY,Tao YY,Liao ZH,Chen M

更新日期：2020-04-01 00:00:00

abstract：:A new γ-pyrone derivative, acrepyrone A (1), and three known sorbicillinoids, trichodimerol (2), dihydrotrichodimerol (3) and tetrahydrotrichodimerol (4) were isolated from an endophytic fungus, Acremonium citrinum SS-g13, harboured in the roots of the Chinese medicinal plant Fructus mori. Their structures were determ...

journal_title：Natural product research

authors： Peng XP,Li G,Ji LX,Li YX,Lou HX

更新日期：2020-04-01 00:00:00

abstract：:A new thiodiketopiperzaine, tedanizaine A (1), together with six known ones, were isolated from the marine sponge Tedania sp. Their structures were determined by spectroscopic analyses. The absolute configuration of 1 was established by ECD calculation. Compound 1 was the second example of thiodiketopiperazine bearing...

journal_title：Natural product research

authors： Zhang H,Lai W,Guan ZB,Liao XJ,Zhao BX,Xu SH

更新日期：2020-04-01 00:00:00

abstract：:Six sesquiterpenoids and four lignans (1-10) were isolated from the n-BuOH extract of the rhizomes of Atractylodes lancea. Among them, the new sesquiterpenoid glycoside named (4 R, 5S, 7R)-hinesolone-11-O-β-ᴅ-glucopyranoside (1), along with three known compounds (2-4) were first obtained from this genus. All the isola...

journal_title：Natural product research

authors： Long L,Wang L,Qi S,Yang Y,Gao H

更新日期：2020-04-01 00:00:00

abstract：:A novel aromatic compound, grandiuvarone B (5-acetoxy-3-benzoyloxymethyl-5H-oxepin-4-one), along with a known compound grandiuvarone A (5-acetoxy-6-benzoyloxymethyl-5H-oxepin-4-one) were isolated from methanol extracts of Desmos chinensis leaves. Their structures were determined by various spectroscopic techniques inc...

journal_title：Natural product research

authors： Zhi QQ,Yan QH,Wang Q,Sun PF,Zhou HY,He ZM

更新日期：2020-04-01 00:00:00

abstract：:An eremophilane-type sesquiterpenoid (EPS), 3-oxo-eremophila-1,7(11)-dien-12,8β-olide, has been isolated from anti-inflammatory folk herbs, Ligularia pleurocaulis. The aim of present study is to explore protective effects of EPS on lipopolysaccharide (LPS)-induced inflammatory responses in acute lung injury (ALI). EPS...

journal_title：Natural product research

authors： Hu Y,Yang H,Ding X,Tao L,Liu M,Zhang C

更新日期：2020-03-31 00:00:00

abstract：:A series of unexpected triterpenic C17-[5-methyl-1,3]-oxazoles along with targeted N-propargylamides was synthesized by an interaction of acid chlorides with propargylamine hydrochloride. We proposed that the formation of methyl oxazole passes through an alternative pathway by the participation of the terminal alkyne ...

journal_title：Natural product research

authors： Khusnutdinova EF,Petrova AV,Lobov AN,Kukovinets OS,Baev DS,Kazakova OB

更新日期：2020-03-28 00:00:00

abstract：:This study investigated the in vitro anticancer potential of phytochemical constituents isolated from the methanolic extract of Eriocephalus africanus. One flavanone (hesperidin) and two flavones (luteolin and apigenin) were isolated for the first time from the plant using column chromatography. Standard MTT assay was...

journal_title：Natural product research

authors： Magura J,Moodley R,Maduray K,Mackraj I

更新日期：2020-03-25 00:00:00

abstract：:Two new C13-norsesquiterpenes claulanterpene A (1) and B (2), together with two known sesquiterpenes (3-4), were isolated from methanol extract of the stem and leaf of Clausena lansium collected from Qingyuan county, Guangdong Province, China. Their structures were elucidated on the base of extensive spectroscopic ana...

journal_title：Natural product research

authors： Liu XY,Fu XX,Li YY,Xiong ZH,Li BT,Peng WW

更新日期：2020-03-25 00:00:00

abstract：:Moringa oleifera Lam. family Moringaceae is well known for a wide range of biological activities and a complex phytochemical composition. The current study investigates tissue culture protocols for Moringa oleifera leaves and seeds. For static culture initiation, Murashige and skooge (MS) as a basal medium with hormon...

journal_title：Natural product research

authors： Mustafa R,El-Naggar EMB,Svajdlenka E,Omran G,ELFiky F,El-Hawiet A

更新日期：2020-03-25 00:00:00

abstract：:Two new 19-hydroxy bufadienolides, named bufohydrolide A (1) and bufohydrolide B (2), and four known analogs (3-6) were isolated from the aqueous extracts of the skins of Bufo melanosticus. Their structures were established by spectral data analyses, such as UV, IR, 1 D/2D NMR and mass spectra. Compounds 1-6 were eval...

journal_title：Natural product research

authors： Meng L,Li S,Kong Q,Wang M,Zhang X,Zhu X,Yu W,Jiang N,Chun Z,Li N,Liu Y

更新日期：2020-03-23 00:00:00

abstract：:Chromatographic purification of the DCM sub-extract of Uvaria grandiflora led to the isolation and characterization of a new polyoxygenated cyclohexane derivative, grandifloranol (1), together with five known compounds. Among the compounds isolated, zeylenone (3) showed moderate antitubercular activity against Mycobac...

journal_title：Natural product research

authors： Macabeo APG,Flores AIG,Fernandez RAT,Budde S,Faderl C,Dahse HM,Franzblau SG

更新日期：2020-03-23 00:00:00

abstract：:The crystal structure and unambiguous absolute configuration of meleagrin (1) isolated from fungus Emericella dentata Nq45 is reported herein to first time on the bases of single crystal X-ray diffraction. Together with 1, haenamindole (2), isorugulosuvine (3), secalonic acid D (4), ergosterol (5) and cerebroside A (6...

journal_title：Natural product research

authors： Hamed A,Abdel-Razek AS,Araby M,Abu-Elghait M,El-Hosari DG,Frese M,Soliman HSM,Stammler HG,Sewald N,Shaaban M

更新日期：2020-03-19 00:00:00

abstract：:Oleiferoside B is a triterpenoid monomer compound, mainly isolated from roots of Camellia oleifera Abel, the underlying mechanism of its antitumour is not clear. In the present study, oleiferoside B potently inhibited SMMC-7721 and MCF-7 cells proliferation and cause cells apoptosis. In addition, it activated an autop...

journal_title：Natural product research

authors： Feng S,Zha Z,Wang Z,Yang P,Wu J,Li X,Xu Q,Liu Y

更新日期：2020-03-18 00:00:00

abstract：:Thirty semicarbazone and thiosemicarbazone derivatives (2a-w and 4a-g) from chalcones containing furan and thiophene ring were designed and synthesized. They were characterized by IR, 1H NMR, 13C NMR and HRMS. The crystal structure of compound 2r was characterized by single crystal X-ray diffraction. It crystallizes i...

journal_title：Natural product research

authors： Cheng W,Xiao T,Qian W,Lu T,Zhang T,Tang X

更新日期：2020-03-16 00:00:00

abstract：:Plumieride (PLU), an iridoid isolated from Allamanda cathartica flowers, has been studied by our research group due to its anti-inflammatory potential, antidepressant-like and anxiolytic-like effects. This research investigated the involvement of GABAergic and monoaminergic systems in the anxiolytic-like effect elicit...

journal_title：Natural product research

authors： Dalmagro AP,Camargo A,Zimath PL,Bonomini TJ,Zeni ALB,Malheiros A,de Souza MM

更新日期：2020-03-11 00:00:00

abstract：:The stem bark of Cussonia bancoensis is used traditionally for the treatment of different types of infection and pain. A bioassay guided fractionation of the methanol stem bark extract led to the isolation of five pentacyclic triterpenes and glycosides identified based on spectroscopic data as 23-hydroxyursolic acid (...

journal_title：Natural product research

authors： Mireku EA,Mensah AY,Amponsah IK,Danquah CA,Anokwah D,Kwesi Baah M

更新日期：2020-03-01 00:00:00

abstract：:New isoquinoline alkaloid hypepontine (1) together with a five known compounds, were identified in Hypecoum ponticum Velen, the partial synonym of Hypecoum procumbens L. The structure of the new substance was elucidated based on spectroscopic evidence. The tertiary and quaternary alkaloid mixtures as well as the isola...

journal_title：Natural product research

authors： Doncheva T,Kostova N,Valcheva V,Toshkovska R,Vutov V,Philipov S

更新日期：2020-03-01 00:00:00

abstract：:A new isoflavonoid, excelsanone (2), was isolated from the ethyl acetate extract of Erythrina excelsa stem bark, together with three known compounds namely 6,8-diprenylgenistein (3), β-sitosterol (1) and sitosteryl-β-D-glucopyranoside (4). Their structures were elucidated using spectroscopic methods (HR-ESI-MS, NMR an...

journal_title：Natural product research

authors： Gbaweng AJY,Daïrou H,Zingué S,Emmanuel T,Tchinda AT,Frédérich M,Mbafor JT

更新日期：2020-03-01 00:00:00

abstract：:Epicatechin (EC) is the most effective compound in Euonymus alatus (Thunb.)Sieb, and possesses a series of benefits, including anti-inflammatory, antioxidant, antiobesity and anticancer effects. In this study, we investigated the protective effects of EC in Acetaminophen(N-acetyl-p-aminophenol, APAP)-induced acute liv...

journal_title：Natural product research

authors： Wu H,Xie Y,Xu Y,Hu Z,Wan X,Huang H,Huang D

更新日期：2020-03-01 00:00:00